Gene Therapy Downstream Process Sciences Senior Scientist

工作内容

To strengthen our new Gene Therapy Bioprocess Development Department, based in Braine, Belgium we are looking for a talented individual to fill the position of: Gene Therapy Downstream Process Sciences Senior Scientist.

The Gene Therapy (GT) Downstream Process Sciences Senior Scientist will be responsible for supporting Downstream Process Development activities for UCB’s recombinant adeno-associated virus (rAAV) gene therapy products. This individual will be accountable for design and management of process development, characterization, and tech transfer of rAAV purification processes.

The Senior Scientist will collaborate with internal and contract laboratories to support development of downstream processes and definition of an AAV production platform for UCB’s gene therapy offerings.

The successful candidate will be part of a team of process scientists and engineers supporting the establishment and operation of a development and manufacturing facility for gene therapy products.

This role will be a scientific leader in the Gene Therapy organization at UCB and will be located at UCB’s Braine l’Alleud site in Belgium. This individual will function remotely during the design and build of the new gene therapy development and manufacturing facility and then will move onsite to support start-up and operation of the development labs when the facility is online. Prior to the facility startup the candidate may also travel (10%) to directly support operations in the United States.

You will more precisely contribute by:

• Act as a downstream process development technical subject matter expert for rAAV gene therapy products supporting facility design, Quality-by-Design (QbD) process development, and pre-clinical and clinical manufacturing.
• Collaborate with internal cross-functional laboratories and external CDMOs.
• Design and execute chromatography and filtration studies for development of processes supporting First in Human studies through commercialization for rAAV gene therapy products.
• Author & review technical documents including CMC regulatory sections, process descriptions, study designs, SOPs, technical position papers, & technical reports.
• Identify, evaluate, and implement new technologies to improve and refine rAAV purification platforms.

Interested? For this position you’ll need the following education, experience and skills:

• PhD (Chemical Engineering, Bioengineering, Biology, Biochemistry, Virology, or related fields) with at least 2 years of experience, 4 years of experience (Master), or 6 years of experience (Bachelor) in process development of large molecule or cellular therapies.
• Excellent technical knowledge of biologics downstream manufacturing and process development (chromatography, TFF, NFF) is required. Experience with AAV manufacturing is a plus.
• Knowledge of cGMP manufacturing guidances and experience with technical investigations and root cause analysis.
• Demonstrated technical project leadership experience
• Very good command in French and English, both spoken and written.

Soft skills:

• Demonstrated technical project leadership skills.
• Interpersonal skills to communicate and maintain good working relationship with internal and external customers.
• Problem solving and drive for results.
• Experience with data and statistical analysis.

Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.

If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.