Post Doc in Statistical Genetics

Jobinhalt

Caring for the world… one person at a time” … inspires and unites the people of Johnson & Johnson. We embrace research and science - bringing innovative ideas, products and services to advance the health and well-being of people. Employees of the Johnson & Johnson Family of Companies work with partners in health care to touch the lives of over a billion people every day, throughout the world. This culture of caring is the focus of our corporate philosophy, that are anchored in the internationally applicable Credo

Post Doc in Statistical Genetics
Position overview

We are excited to announce a new 4-year postdoc (funded by Horizon 2020, a funding mechanism in Europe) for result-oriented early career researcher with expertise in statistics genetics to work on GWAS, WES, and WGS data to conduct research in neuropsychiatric diseases and treatment response with a focus on schizophrenia, depression, and bipolar disorder (>=20K samples from neuropsychiatric diseases from Company Sponsored Clinical Studies (many of them are randomized controlled trials (RCT)) with rich/deep phenotype data and collaborative study studies. The postdoc will be dedicated to the Horizon 2020 project REALMENT with the main aim being to bring personalized medicine interventions to psychiatry across Europe. Building on Real-Word Data (RWD), the consortium will develop: i) a sustainable data infrastructure (REAL-WD platform) to facilitate access to RWD data across Europe; ii) novel artificial intelligence (AI) and machine learning (ML) tools to exploit large datasets/volumes of data; iii) a clinical management platform (4MENT) with algorithms for medication response and adverse effects to significantly improve patient outcomes and quality of life. Being the company with extensive RCT data participating in the consortium, REALMENT provides a unique opportunity to validate findings from RCTs (short term, monotherapy) in RWD (long term, polypharmacy) and vice versa. The postdoc will therefore be focusing on the genetic and clinical data generated from the RCT and collaborative studies but has the opportunity to interact with other consortium leaders from world leading institutes and laboratories. The postdoc will be a member of Neuroscience Data Science team in Janssen Research & Development, LLC (JRD) with presence in both United States and Europe and be exposed to other multi-omic/digital phenotyping/RWE projects and interacting with other organizations on drug discovery and drug development efforts, and gain the first-hand experience on the clinical trial study design to meet the requirement of health authority in order to bring life-changing therapy to the patients with unmet medical needs.
The position will be based in Beerse, Belgium (considered as an employee of (Janssen Pharmaceutica NV (JPNV), both JPNV and JRD are subsidiary of Johnson & Johnson). Other locations (especially locations where Johnson & Johnson has a presence such as Sweden Office (where KI close by is a participating REALMENT consortium member) could be considered on a case-by-case basis.
Tasks & Responsibilities:

- Perform common/rare variant genetic analysis using GWAS, whole genome sequencing data
- Collaborate with Consortium members to jointly fulfill the commitments in the funding proposal such as cross-replication of findings and models
- Independently summarize the analysis into externally presentable format such as consortium reports and manuscripts