GT PCR Laboratory Scientist

le contenu du travail

Make your mark for patients.We’re here because we want to build the future and transform patients’ lives for the better.At UCB, our people are our experiences and achievements, our passion and drive. That’s why we’re looking for talented individuals with diverse backgrounds and experiences - not just the best and brightest, but those who care about making a meaningful difference in the lives of patients. We promote an environment of diversity, openness, and respect where people can make valuable contributions.An exciting journey lies ahead. Will you join us in pushing the boundaries of what’s possible?UCB is a leading global pharmaceutical company, dedicated to the research, development and commercialization of innovative pharmaceutical and biotechnology products in the areas of Neuroscience, Immunology and Oncology. The organization employs some 9000 individuals across approximately 40 countries. UCB is a pharmaceutical company with a size which enables it to deliver a significant drug pipeline, whilst remaining agile and innovative. For our talented scientists there isplenty of scope to influence the pipeline and make a difference to patientsand greatpotential to influence the strategy and drive the science. UCB remains a great opportunity for the individual to get a breadth of experience of the drug pipeline from research through to the clinic, whilst working in a highly collaborative environment to learn, contribute and gain visibility in a scientific and cross functional setting.To strengthen our Translational Biomarkers and Bioanalysis (TBB) team, we are looking for a talented individual to fill the position of GT PCR Laboratory Scientist,based in Braine-l’Alleud, Belgium.The Translational Biomarkers and Bioanalysis (TBB) Department is positioned within the function of Development Sciences, a division which provides strategy and support to transition novel pharmacological assets, including gene therapy derived assets, from research into the clinic. TBB operate and collaborate closely across the organization to support bioanalysis and biomarker activities.As part of the growth of UCBs gene therapy portfolio, the Translational Biomarkers and Bioanalysis group is looking for a highly skilled, experienced and self-motivated lab-based scientist to contribute to the validation and sample testing using PCR assays and other lab-based capabilities to advance our gene therapy assets. This scientist will focus on regulated gene therapy-based bioanalysis and work in the area of biodistribution analysis via quantitative PCR in support of pre-clinical and clinical studies. The successful candidate will operate in a GLP/GCP compliant facility to support assets from regulated tox and onwards, contributing to the transfer of assays into the regulated environment.The successful candidate will have a strong scientific background, good written and verbal communication skills and be able to multi-task effectively and adapt to meet the demands of a fast-paced matrix-team environment.Main Accountabilities

• You will employ your proven expertise to contribute to the implementation of regulated Gene therapy bioanalytical activities including setting up of the laboratory and the quality management system.
• You will be responsible running validation, and sample testing experiments
• You will be the regulated bioanalyst supporting pre-clinical and clinical studies
• Work with key stakeholders to ensure prioritization and optimal deployment of technologies
• Work with scientists in the Non-regulated GT area for the successful transfer of assays
• Ensure compliance with all health and safety regulations
• Maintain an awareness of new / emerging techniques and tools relevant to the field to ensure the group remains state of the art
• Represent and align with the objectives of Development Sciences internally and externally

Interested? For this position you’ll need the following education, experience and skills:Minimum Qualifications

• Extensive and proven experience in running PCR assays, preferably in gene therapy application
• Clear practical experience in a range of methodologies, including RNA and DNA extraction in a range of matrices
• Technical understanding and experience across a wide array of PCR and ddPCR platforms and techniques
• Has the quality mindset to work in GXP compliant facility as a lab scientist
• Capable of performing validation and sample testing activities of PCR assays effectively and delivery to key deadlines
• Demonstrated ability to analyze and present critical data sets in collaboration with statisticians and other colleagues
• English: fluent, both oral and written. French will be considered a plus

Specific Skills, Competences

• Previous experience of working in a pharmaceutical drug discovery and development environment in a GLP/GCP compliant context
• Experience running assays to assess immunogenicity including cell-based assays
• Experience in running assays in support of PK assessment for a novel biological entity (LBA assays)
• Understanding of regulatory standards and industry best practices for PK and Immunogenicity assays
• Experience working with Quality Assurance colleagues
• Experience in writing of SOPs to support regulated activities

Why you should applyAt UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration, and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.RANDATUCBAbout Us.UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are around 7,600 people in all four corners of the globe, inspired by patients and driven by science.At UCB, everything we do start with a simple question: “How will this create value for people living with severe disease?”. We are on a journey to become the patient-preferred biopharma leader by delivering medicines and solutions that improve lives. We want to ensure the creation of patient value, now and into the future, while contributing to a society where a population of 8 billion people and more should be able to live a good life within limited resources of one planet.Curious to know more? Please visit our website www.ucb.com .UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. We do not discriminate on the basis of race/color/religion/sex/national origin/veteran/disability/age/sexual orientation/gender identity.