Postdoctoral position to study genomic resilience against neurodegeneration

☞ VIB

Vue: 29

Jour de mise à jour: 05-12-2025

Localisation: Leuven Flemish Brabant

Catégorie: R & D IT - Logiciel

Industrie: Non-profit Organizations

Type d’emploi: Other

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le contenu du travail

The Holstege lab, with locations in both in Amsterdam and Leuven, aims to unravel protective mechanisms against neurodegeneration by investigating cognitive healthy centenarians: those who live to extreme ages without dementia.

The Leuven team is leveraging brain samples from this remarkable cohort and will contrast them to an age continuum of healthy donors and individuals affected by various forms of neurodegeneration, totaling to over 1,500 human brain samples. Using an array of -omics techniques, e.g. long read DNA sequencing, single nuclei transcriptomics and multi-modal proteomics, the team aims to identify genetic and genomic features that may convey protection against aging and neurodegeneration.

We expect the candidate to computationally address biological questions concerning resilience against neurodegeneration both within as well as across -omics modalities, leveraging both in house as well as public databases. Expertise in the data analysis of one of the modalities that we will use in this project (single cell transcriptomics, proteomics or long-read DNA or RNA sequencing) will therefore be desirable. Tight collaboration with the bioinformatics team in Amsterdam will be critical, thus good communication and organization skills are warranted. Given the size of the project, we also expect close collaboration with the wet lab team to optimize workflows and procedures and to aid in data quality control, storage and maintenance.

Profile

We are seeking a highly motivated, efficient, energetic and optimistic postdoctoral fellow, with a strong interest in aging and neurodegeneration and a firm background in bioinformatics, to join our team in Leuven.

A Successful Candidate

  • Has a master’s degree in Bioinformatics and affinity with Computer Science, Bio-engineering and Life Sciences
  • Is proficient in pipeline design, not only the application of existing pipelines
  • Has experience with at least one of the following techniques: proteomics (lipidomics, shot gun proteomics, phosphoproteomics), single cell RNAseq, long read DNA/RMA sequencing;
  • Has experience with programming, data visualization and data handling in Python, R or related languages;
  • Is proficient in Unix/Linux-based command line and cluster environments;
  • Has strong verbal and written English communication skills;
  • Is pro-active, efficient, well organized, independent and a team-player.

We offer

  • An exceptionally strong and international scientific research environment;
  • Access to state-of-the-art infrastructure and technical support;
  • A competitive compensation package based on expertise and experience;
  • Financial support is available for at least 2 years. However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or National funding organizations).
  • Starting Date: as soon as possible

How to apply?

Motivated candidates with a strong interest in neurodegeneration, a team player mindset, and with a strong commitment to computational research are invited to apply. Please complete the online application procedure and include a motivation letter, CV (including a list of publications), a short synopsis of past research and the contact information of 2 to 3 referees. The best-ranked candidates will be invited for an interview. For further information and questions, please send an email to Annerieke Sierksma (annerieke.sierksma@kuleuven.be).

  • Find out more about the Holstege lab: Holstege Lab - Home
  • Connect through our LinkedIn page
  • Discover the Center by visiting the website or looking around in our a virtual tour
  • Follow the Center on social media: Instagram and Bluesky
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Date limite: 04-01-2026

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