Scientist, Bioanalysis

工作内容

Working with Johnson & Johnson can change everything. Including YOU. Janssen Research & Development, NV., a division of Johnson & Johnson’s Family of Companies is recruiting for a Scientist, Bioanalysis for our site in Beerse, Belgium. At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing, and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information. We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees, and committed to inclusion. Proud to be an equal opportunity employer. DMPK (drug metabolism and pharmacokinetics) is committed to the delivery of key ADME (absorption, distribution, metabolism, and excretion) and pharmacokinetics and pharmacodynamics data across therapeutic areas. This mission requires deep scientific expertise in various disciplines including bioanalysis, drug metabolism, pharmacokinetics, and chemistry as well as superior compliance for data integrity. The Development Bioanalysis group within DMPK supports quantitative analysis for a diverse range of activities including in-house bioanalytical support and the monitoring of out-sourced bioanalytical activities, and biomarker bioanalysis support. We are currently seeking a highly motivated individual to join our team as Scientist in the Development BA group. This position will be based in Beerse, Belgium Job Description: As a member of the Development BA team, you will support quantitative and qualitative assessment of oligonucleotides and their metabolites in biological matrices, primarily by LC-MS/MS. A large portion of the work will be providing hands-on support in the bioanalytical lab. You will also explore platforms beyond LC-MS such as qPCR and hybridization ELISA for bioanalytical support of oligonucleotide programs in discovery and development. You will enhance the analytical capability of the group to support mechanistic ADME investigation of oligonucleotides in cell-based models and in vivo measurements of intracellular distribution and endosomal release. You will play a key role in strengthening our bioanalytical capabilities of oligonucleotides and assist in resolving issues for all programs. You will be part of a dynamic team that focuses on innovative modalities, state of art analytical tools, and provide analytical solutions for challenging biological questions to bring novel therapeutics to patients. Qualifications Requirements A Ph.D. degree preferably in biochemistry, (Analytical)chemistry, biomedical sciences, pharmacology Extensive knowledge and hands-on experience of (micro/nano) liquid chromatography and mass spectrometry (both triple quadrupole and high-resolution MS) Hands-on experience with quantitative bioanalysis in complex biological matrices such as plasma, serum, and tissue, specifically for oligonucleotides and proteins. Hands-on experience with bioanalytical sample preparation skills, such as solid phase extraction, liquid-liquid extraction, immuno-affinity enrichment Knowledge and experience with bioanalysis method development and assay establishment and strong capability to independently troubleshoot Understanding of ADME and pharmacokinetics Prior analytical experience with protein and oligonucleotides (LC-MS, qPCR, or hybridization ELISA etc) is a plus. Hands on experience with qPCR and ELISA based techniques is a plus The ideal candidate should possess a very strong and critical analytical mindset and willing to work across different departments Are you ready to make an impact? If you want to leave your personal mark and be valued for who you are, Johnson & Johnson offers an unusual experience to professionals looking for an opportunity to work with hardworking people who share your real passion for caring in an environment that empowers you to drive your own career and that you feel you can bring your whole self to work. We provide you an environment to fulfil your career aspirations as well as promoting your physical and mental wellbeing. You will receive a competitive compensation and benefits package as well as benefits that can be tailored to what is valuable to you throughout different stages of your life. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Ready to be part of something great? Don’t forget to apply. We want YOU! Primary Location Belgium-Antwerp-Beerse- Organization Janssen Pharmaceutica N.V. (7555) Job Function R&D Requisition ID 2105974976W