(Junior/Senior) Associate Scientist DSP / Purification

Contenuto del lavoro

(Junior/Senior) Associate Scientist DSP / Purification

About The Opportunity

Join Ablynx, a Sanofi company, as Associate Scientist in the DownStream Processing (DSP) team within the Chemistry Manufacturing and Control (CMC) Pharmaceutical Development & Technology Department.

You will be part of a dynamic, international and fun team consisting of :28 people with different levels of experience and you will have the opportunity to work alongside some of the top experts within our field using state-of-the-art equipment and workflows allowing a steep learning curve in the wonderful world of downstream processing.

About Ablynx And The DSP Department

Ablynx, a Sanofi company, is a biopharmaceutical company dedicated to creating new antibody-based medicines called Nanobodies® which are making a real difference to society. Ablynx currently has over 400 people working on the development of Nanobodies for the treatment of a wide range of diseases, including inflammation, immuno-oncology and rare diseases.

The DSP team is responsible for:

• CMC-grade research batch purifications to deliver Nanobody® batches for all projects running in Ablynx;
• Development of DSP processes for Nanobody® pre-candidates during pre-clinical development;
• Large-scale DSP activities (purification of tens to thousands of grams), including in-house production of non-GMP DS for toxicology studies;
• DSP-related activities to support late-stage projects (e.g. PAR studies and process validation);
• DSP platform improvement and new Technology exploration.
  
  

About Growing With Us

Responsibilities (Jr) Associate Scientist level:

• Use state-of-the-art equipment (AKTA, Sartorius, TECAN) and different types of column and membrane chromatography (affinity, IEX, HIC, mixed mode) and filtration (µ-filtration and ultrafiltration TFF, depth filtration) techniques to perform generic purification in a timely manner with eye for quality;
• Be part of the team that performs large-scale DSP campaigns to facilitate Tech Transfers to CMO (Man-in-Plant runs) and provide non-GMP DS material for Tox studies;
• Report about the results and progress to the line and/or project supervisor, project team and project leader;
• Prepare experimental reports (eLN), meeting summaries/presentations and drafts working protocols in English;
• Responsible for one or more lab responsibilities to keep the different DSP platforms and labs operational at all times.
  
  

Responsibilities Sr Associate Scientist level:

• Be part of a team that, using a Design-of-experiment (Doe) approach and high-throughput equipment (TECAN robotics and AKTA Avant), develops a DSP process for Nanobody® Development Candidates which has a high process yield, delivers high quality Nanobody material, is robust and scalable and can be successfully transferred to a CMO of choice for GMP manufacturing of Nanobody batches for clinical studies;
• Responsible for exploring new DSP-related technologies and improving platform workflows in an independent manner;
• Responsible for presenting results at internal team meetings;
• Responsible for (technical) coaching of more junior colleagues in the team.
  
  

About You

Qualifications/ Education & work experience (Jr) Associate Scientist:

• B. Sc., M. Sc. Biotechnology/(Bio)chemistry/Pharmacology/Industrial engineer or equivalent field; or a proven track record within biotechnology;
• Excellent communication skills (fluent in English, written and spoken as English is the official communication language);
• Knowledge of Word, PowerPoint and Excel.
  
  

Competencies (Jr) Associate Scientist:

• Sense for initiative, quality and accuracy;
• Ability and desire to work in a fast-paced, dynamic environment;
• Team player, enthusiastic and flexible.
  
  

In addition, as a Sr Associate Scientist you should have:

• At least 5 years of experience in laboratory work;
• Hands-on experience in purification of biological expressed in P.pastoris and/or E.coli;
• Knowledge of DSP process development (different types of resin screening, Design-of-Experiment (DOE) approach for process development, gradient optimization, etc…);
• Hands-on experience in using (AKTA or related) chromatography and filtration equipment;
• Familiar with digitalization concepts and applied data sciences using advanced applications (Spotfire, R, JMP);
• Proven organizational skills;
• Good troubleshooting skills;
• Able to coach more junior colleagues;
• Experience in using TECAN workstation (script writing and handling) is a plus.
  
  

Please make sure your attached CV contains a paragraph describing your technical expertise.

People applying for a (Jr) Associate Scientist level position will be offered a temporary contract (12 months), with a possibility to extend or convert into a permanent contract.

People applying for a Sr Associate Scientist level position will be offered a permanent contract.

Inspire your Journey, what Sanofi can offer you:

• An international work environment, in which you can develop your talent and realize ideas and innovations within a competent team;
• An individual and well-structured introduction and training when you onboard;
• You can create your own career path within Sanofi. Your professional and personal development will be supported purposefully;
• As a globally successful and constantly growing company, Sanofi provides international career paths as well.
  
  

This is our Sanofi, Discover yours.

We are proud to have been awarded Global Top Employer 2021.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.