PhD student to work on the genetics of epilepsy

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PhD student to work on the genetics of epilepsy using computational and statistical approaches on large multi-omics dataThe Weckhuysen team at the VIB-UAntwerp Center for Molecular Neurology, Belgium is seeking a highly motivated PhD student to work on the genetics of epilepsy using computational and statistical approaches on large multi-omics data. The Weckhuysen team performs leading-edge research in gene discovery and mutation analysis using short and long-read sequencing, transcriptomics, and iPSC-based disease modeling to better understand the genetic etiologies of intractable epilepsy.About The ProjectEpilepsy is a common chronic brain disease affecting more than 50 million people worldwide. Despite major advances in therapy, 1/3 of individuals remain drug-resistant. Many also develop co-morbid behavioral and neurodevelopmental problems, making epilepsy a major public health problem. Epilepsy can have various etiologies, but especially in childhood-onset epilepsies genetics plays a central role. Over half of children who develop epilepsy will not have a definitive diagnosis using current genetic approaches. Making a genetic diagnosis is however key to providing effective and individualized therapy. We combine trios long-read whole genome sequencing with whole genome methylomics and transcriptomics to pin down novel genetic causes of disease. Recently, we have also begun analyzing cell-free DNA for unique methylation patterns and somatic mutations that can further explain the missing diagnostic gap.Your profileWe seek a highly motivated, enthusiastic, critical, and creative individual to join our team. The candidate should have a strong interest in bioinformatics, biostatistics, and genetics.Essential

• Master’s in biochemistry, biomedical sciences, bioinformatics, (bio)statistics, computer science, related disciplines or equivalent through experience
• Proficient in verbal and written English.
• Ability to summarize data extracted from literature and to define research objectives.
• Passion for science, self-motivation, flexibility, and team spirit

Desirable But Not Required

• Programming experience, preferably in Python or R
• Experience with data analysis and working in the Linux environment
• Experience with large-scale data, such as genomics and transcriptomics data
• Experience with a workflow management system such as Snakemake or Nextflow
• A willingness to learn and apply machine-learning approaches

We offer

• A versatile and challenging job in a vibrant world-class research environment operating at an international level
• State-of-the-art research facilities
• A dedicated training program to broaden your expertise and enhance your skill set
• A doctoral scholarship for a period of one year, with the possibility of renewal for a further three-year period after positive evaluations.
• During the doctoral scholarship, you will be asked to submit and defend an innovative project at the FWO (www.fwo.be) to obtain a personal fellowship. Please check eligibility criteria prior to applying for this position.

Starting date: as soon as possibleJoin us → how to apply?Submit your application through the VIB online application tool. Be sure to include:

• a detailed CV incl. a list of previous experience
• a letter of motivation explaining why you are interested in our work and aspire to this PhD position
• the names and contact details of 3 references

For more information, please contact tejasvi.niranjan@uantwerpen.vib.beFor more information about our research center https://weckhuysenlab.sites.vib.be/en