(Senior) Scientist Comminution in the Crystallization Technology Unit

Job content

Caring for the world… one person at a time” … inspires and unites the people of Johnson & Johnson. We embrace research and science - bringing innovative ideas, products and services to advance the health and well-being of people. Employees of the Johnson & Johnson Family of Companies work with partners in health care to touch the lives of over a billion people every day, throughout the world. This culture of caring is the focus of our corporate philosophy, that are anchored in the internationally applicable Credo

(Senior) Scientist Comminution in the Crystallization Technology Unit (CTU)
Position overview

Do you want to contribute to the discovery of a medical breakthrough and a world without disease?
Join our team in the Crystallization Technology Unit (CTU) at Janssen Research & Development to develop novel comminution/bottom-up technology to produce stabilized nano- and micron-sized active pharmaceutical ingredients (APIs).

We collaborate in project teams of various therapeutic areas such as oncology, immunology, and neuroscience, delivering APIs with consistent product quality and well-defined solid-state characteristics. As these properties directly influence metabolic uptake and in-vivo performance, our development work plays a crucial role in health-care supply to patients all around the globe.

To strengthen our research and development work in comminution, we are looking for a highly motivated Scientist or Senior Scientist with hands-on mentality and demonstrated knowledge in this field. The successful candidate will join our multidisciplinary team in the CTU-group, developing processes to alter material properties such as particle size distribution, morphology, bulk density, and powder flowability. As these properties impact the formulation, this work is performed in close collaboration with the Drug Product group.

What is in it for you
- Become part of an enthusiastic and experienced research team (ca. 20 people) in an innovative global working environment.
- Access to state-of-the art facilities, including high tech PAT equipment and skilled team members, all located on the site in Beerse, Belgium.
- Through mentoring programs, e-university and on the job training, we ensure your personal development in a global company.
- A market-competitive re-numeration package including numerous fringe benefits
- An inspiring work-life balance: on-site sport facilities, health/energy programs and other benefits for you and your family.
- Flexible working hours (40 h/week), no fixed holiday planning and possibility to work at home for non-laboratory related tasks.
- A work environment open to any individual with a scientifically driven and practical mind set

Tasks & Responsibilities:

- Broaden the knowledge base of comminutions, conditioning, and particle size stabilization processes in the manufacturing of small molecules, peptides, and oligo nucleotides.
- Independently conceptualize and conduct experimental studies to gain mechanistic insights and develop a scalable dry comminution and conditioning process
- Develop predictive comminution models related to material properties
- Provide feedback to the crystallization experts on API solid-state characteristics (crystallinity, size, stability, …) after grinding.
- Capture, analyze, correlate, and interpret data from various sources: PAT data (Insitec, Relative humidity, PVM, IR spectroscopy), offline analytical data (SEM, UPLC, XRD, DSC, Laser Diffraction, …), etc.
Collaborate with a multidisciplinary team during process development, including (R&D chemists, Pharmaceutical Sciences, Drug Product Development, API manufacturing) to keep a holistic overview and align on the project results.